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Showing 1–6 of 6 results
Advanced filters: Author: Julia D. Ransohoff Clear advanced filters

  • Here, in a cohort of 772 women undergoing triple-negative breast cancer (TNBC) therapy, the authors show that antimicrobial prescription during TNBC treatment associates with inferior overall and breast cancer-specific survival, in turn related to peripheral lymphocyte count and gut microbiome dysbiosis.

    • Julia D. Ransohoff
    • Victor Ritter
    • Allison W. Kurian
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Efficient repair of demyelinated CNS lesions involves the resolution of inflammation and induction of remyelination. Berghoff et al. show that sterol synthesis in microglia is key to both processes, which can be supported by squalene therapy.

    • Stefan A. Berghoff
    • Lena Spieth
    • Gesine Saher
    Research
    Nature Neuroscience
    Volume: 24, P: 47-60

  • Long intergenic non-coding RNAs (lincRNAs) do not overlap protein-coding genes, although some lincRNA genes have minimal coding potential and can include small open reading frames that encode functional peptides. lincRNA functions include RNA stabilization and transcription regulation and the remodelling of chromatin and genome architecture. Recent insights suggest that lincRNAs broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity.

    • Julia D. Ransohoff
    • Yuning Wei
    • Paul A. Khavari
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 143-157

  • The preclinical intersection of molecular imaging and gene- and cell-based therapies will enable more informed and effective clinical translation. We discuss how imaging can monitor cell and gene fate and function in vivo and overcome barriers associated with these therapies.

    • Nigel G. Kooreman
    • Julia D. Ransohoff
    • Joseph C. Wu
    Comments & Opinion
    Nature Materials
    Volume: 13, P: 106-109