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Showing 1–5 of 5 results
Advanced filters: Author: Julia Niessl Clear advanced filters

  • Peripheral ancestral SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by BNT162b2 vaccination cross-react to the Omicron variant at higher levels than those induced by prior SARS-CoV-2 infection.

    • Yu Gao
    • Curtis Cai
    • Marcus Buggert
    ResearchOpen Access
    Nature Medicine
    Volume: 28, P: 472-476

  • The role of IFN signaling in SARS-CoV-2 infection and outcome is still debated. Here, the authors longitudinally profiled plasma samples from hospitalized patients and show that a persistent inflammatory response is linked to delayed generation of adaptive immunity and increased risk of death when coupled with severe infection.

    • Elsa Brunet-Ratnasingham
    • Sacha Morin
    • Daniel E. Kaufmann
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • HIV infection results in T cell dysfunction. Kaufmann and colleagues demonstrate that HIV infection results in an alterated differentation of HIV-specific CD4+ T cells that is only partially reversed by antiretroviral therapy and generation of dysfunctional T cells with a follicular helper-like phenotype.

    • Antigoni Morou
    • Elsa Brunet-Ratnasingham
    • Daniel E. Kaufmann
    Research
    Nature Immunology
    Volume: 20, P: 1059-1070