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Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer

Elevated levels of Dickkopf-1 (DKK1), a soluble inhibitor of the Wnt/β-catenin pathway, are associated with poor prognosis in patients with breast cancer. Here the authors show that bone- and cancer-associated fibroblast-derived DKK1 contribute to breast cancer progression by suppressing NK cell cytotoxicity

Seunghyun Lee
Biancamaria Ricci
Roberta Faccio
ResearchOpen Access30 Jan 2025
Nature Communications

Volume: 16, P: 1-19
Paleosecular variation recorded by Quaternary lava flows from Guadeloupe Island

Julia Ricci
Julie Carlut
Jean-Pierre Valet
ResearchOpen Access05 Jul 2018
Scientific Reports

Volume: 8, P: 1-14
Developing and interpreting models to improve diagnostics in developing countries

Developing a strategy for investment in diagnostic technologies requires an understanding of the need for, and the health impact of, potential new tools, as well as the necessary performance characteristics and user requirements. In this paper, we outline an approach for modelling the health benefits of new diagnostic tools.

Federico Girosi
Stuart S. Olmsted
Jeffrey Wasserman
Research22 Nov 2006
Nature

Volume: 444, P: 3-8
Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

Discovery, biochemical and structural characterization of exoglycosidases from Akkermansia muciniphila reveals combinations that efficiently target extended A and B blood group antigens to produce ABO-universal blood for transfusions.

Mathias Jensen
Linn Stenfelt
Maher Abou Hachem
Research29 Apr 2024
Nature Microbiology

Volume: 9, P: 1176-1188
Intercontinental comparison of optical atomic clocks through very long baseline interferometry

Very long baseline interferometry is used to compare two optical clocks located in Japan and Italy through the observation of extragalactic radio sources. This approach overcomes limitations of the performance of satellite transfer techniques.

Marco Pizzocaro
Mamoru Sekido
Tetsuya Ido
Research05 Oct 2020
Nature Physics

Volume: 17, P: 223-227
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy

Julia Davis-Porada
Ceren Tozlu
Donna L. Farber
ResearchOpen Access17 May 2025
npj Vaccines

Volume: 10, P: 1-10
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation

Hang Fu
Mohamad Alabdullah
Harald Loppnow
ResearchOpen Access21 Nov 2019
Cell Death & Disease

Volume: 10, P: 1-17

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Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer

Paleosecular variation recorded by Quaternary lava flows from Guadeloupe Island

Developing and interpreting models to improve diagnostics in developing countries

Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

Intercontinental comparison of optical atomic clocks through very long baseline interferometry

Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Durable T cell immunity to COVID-19 vaccines in MS patients on B cell depletion therapy

Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

The differential statin effect on cytokine production of monocytes or macrophages is mediated by differential geranylgeranylation-dependent Rac1 activation

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