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Showing 1–4 of 4 results
Advanced filters: Author: Julia Romanov Clear advanced filters

  • Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin condensate formation and degradation by autophagy.

    • Eleonora Turco
    • Adriana Savova
    • Sascha Martens
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Complex genomic alterations segregate melanoma into different molecular subsets, but for most subsets it is unclear whether they drive a distinct clinical behaviour. Here, the authors use gene-expression data from melanoma patients to search for outlier genes that correlate with survival and identify that MTSS1 is associated with metastasis.

    • Kirsten D. Mertz
    • Gaurav Pathria
    • Stephan N. Wagner
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • The Cvt pathway in yeast operates constitutively, but the mechanism by which non-cargo material is excluded from the vacuole is incompletely defined. Martens and colleagues show that cargo binding to the cargo receptor Atg19 exposes further Atg8 binding sites on the receptor, which draws the isolation membrane around the autophagic cargo and prevents inclusion of non-cargo material in autophagosomes.

    • Justyna Sawa-Makarska
    • Christine Abert
    • Sascha Martens
    Research
    Nature Cell Biology
    Volume: 16, P: 425-433