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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

Discovery, biochemical and structural characterization of exoglycosidases from Akkermansia muciniphila reveals combinations that efficiently target extended A and B blood group antigens to produce ABO-universal blood for transfusions.

Mathias Jensen
Linn Stenfelt
Maher Abou Hachem
Research29 Apr 2024
Nature Microbiology

Volume: 9, P: 1176-1188
The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action

Julia Weikum
Alina Kulakova
J. Preben Morth
ResearchOpen Access04 Dec 2020
Scientific Reports

Volume: 10, P: 1-18

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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood

The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action

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