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Showing 1–4 of 4 results

Advanced filters: Author: Juliann B. Tefft Clear advanced filters

Highly multiplexed 3D profiling of cell states and immune niches in human tumors

Confocal microscopy enables high-resolution, high-plex 3D cyclic immunofluorescence of 30- to 50-µm-thick tissue sections. The approach allows for rich phenotypic assessments of intact cells and intercellular interactions with subcellular resolution.

Clarence Yapp
Ajit J. Nirmal
Peter K. Sorger
ResearchOpen Access29 Sept 2025
Nature Methods

Volume: 22, P: 2180-2193
Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option

Uroz et al. report that the distinct mechanical properties of brain vasculature versus parenchyma drive cancer cell migration through a talin-dependent mechanism, enabling vessel co-option and metastatic invasion in the brain.

Marina Uroz
Amy E. Stoddard
Christopher S. Chen
Research24 Oct 2024
Nature Cell Biology

Volume: 26, P: 2144-2153
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers

Sorger and colleagues present Orion, a technique to analyze H&E histology and multiplex immunofluorescence imaging data from the same cells, which they apply to human colorectal cancer samples to identify spatial biomarkers of disease progression.

Jia-Ren Lin
Yu-An Chen
Peter K. Sorger
ResearchOpen Access22 Jun 2023
Nature Cancer

Volume: 4, P: 1036-1052
Microfabricated blood vessels for modeling the vascular transport barrier

Cells are seeded into an extracellular matrix template and flow is applied to create microfabricated blood vessels.

William J. Polacheck
Matthew L. Kutys
Christopher S. Chen
Protocols05 Apr 2019
Nature Protocols

Volume: 14, P: 1425-1454