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Showing 1–3 of 3 results
Advanced filters: Author: Julie Lucifora Clear advanced filters

  • Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.

    • Carla Eller
    • Laura Heydmann
    • Thomas F. Baumert
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Current treatments efficiently control chronic HBV infection but they do not lead to its elimination. Now, Ebert and colleagues have shown that cellular inhibitor of apoptosis proteins (cIAPs) prevent TNF-mediated killing of infected hepatocytes and that cIAP antagonists might lead to HBV cure by promoting death of infected cells.

    • Julie Lucifora
    • Christian Trepo
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 376-378