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Showing 1–4 of 4 results
Advanced filters: Author: Julie Rayes Clear advanced filters

  • Sepsis is a life-threatening condition where exaggerated inflammatory responses lead to severe tissue damage. Here, Rayes and colleagues show that the interaction between podoplanin and its receptor CLEC-2 on platelets plays a critical role in limiting inflammation during sepsis.

    • Julie Rayes
    • Siân Lax
    • Steve P. Watson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Cryptococcal meningitis is a common infection in patients with compromised CD4 T cell function. Using a CD4 T cell activation tracking mouse the authors show the localisation and activation of CD4 T cells in the brain after cryptococcus infection and how these cells interact with MHCII expressing microglia which may increase pathologic brain inflammation.

    • Sofia Hain
    • Man Shun Fu
    • Rebecca A. Drummond
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Infection may induce multi-organ thrombosis, but the underlying inflammatory mechanism remains elusive. Here, using Salmonella Typhimurium infectious mouse model, the authors reveal organ specific and broad inflammatory events like TNF for thrombosis in liver and spleen.

    • Marisol Perez-Toledo
    • Nonantzin Beristain-Covarrubias
    • Adam F. Cunningham
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • This protocol can be used to generate three-dimensional vascularized bone marrow organoids from human induced pluripotent stem cells. The organoids contain key stromal and hematopoietic cell types and can be engrafted with normal and malignant cells from adult donors to model niche interactions.

    • Aude-Anais Olijnik
    • Antonio Rodriguez-Romera
    • Abdullah O. Khan
    Protocols
    Nature Protocols
    Volume: 19, P: 2117-2146