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Showing 1–5 of 5 results
Advanced filters: Author: Julien Ablain Clear advanced filters

  • Loss of NECTIN1 is a frequent event in human melanoma and is associated with metastasis. NECTIN1 depletion modulates a switch from cell–cell adhesion to cell–matrix adhesion in response to low levels of IGF1 signaling from the microenvironment.

    • Julien Ablain
    • Amira Al Mahi
    • Leonard I. Zon
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1839-1852

  • This Review outlines the recent advances in the creation of both combinatorial transgenic cancer models in zebrafish and zebrafish patient-derived xenograft models, and argues that these models have potential to be used as avatars for precision oncology.

    • Maurizio Fazio
    • Julien Ablain
    • Leonard I. Zon
    Reviews
    Nature Reviews Cancer
    Volume: 20, P: 263-273

  • There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model.

    • Jiyeon Choi
    • Tongwu Zhang
    • Kevin M. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Retinoic acid and arsenic therapies have shown considerable efficacy in patients with acute promyelocytic leukemia, but their exact mechanism of action remains unclear. Here, Hugues de Thé and colleagues uncover a therapeutic effect mediated by nuclear body reformation and p53 activation that involves the induction of a senescence transcriptional program. These data suggest that redifferentiation and apoptosis induction may not be sufficient for the effect of these agents in patients and uncover alternative therapeutic routes that could be applied to other tumor and treatment types.

    • Julien Ablain
    • Kim Rice
    • Hugues de Thé
    Research
    Nature Medicine
    Volume: 20, P: 167-174