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Showing 1–4 of 4 results
Advanced filters: Author: Julien Bous Clear advanced filters

  • FZD7 is a class F GPCR involved in intestinal epithelium homeostasis. Using cryo-EM, the authors determine the structure of inactive FZD7 and compare it with the G-protein-bound form. They refine the FZD activation mechanisms and identify a water pocket and an allosteric cholesterol binding site.

    • Julien Bous
    • Julia Kinsolving
    • Gunnar Schulte
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • To help in the rational design of new compounds for treating hyponatremia and polycystic kidney disease, the authors solve cryo-EM structures of the G protein-coupled vasopressin type 2 receptor in its inactive state, bound to a small molecule or to a mini-protein from snake venom.

    • Aurélien Fouillen
    • Julien Bous
    • Bernard Mouillac
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Aryl hydrocarbon receptor (AHR) is a sensor of the chemical environment including pollutants, diet components and metabolites. Here, authors determine the structure of the indirubin-bound AHR cytosolic complex providing mechanistic insights into ligand-binding promiscuity and selectivity.

    • Jakub Gruszczyk
    • Loïc Grandvuillemin
    • William Bourguet
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Signaling pathway selectivity downstream of GPCRs is not fully understood. Here, authors perform functional analysis of Frizzled mutants to uncover state-stabilizing residues or ‘micro-switches’ mediating selectivity towards Disheveled over G proteins.

    • Lukas Grätz
    • Maria Kowalski-Jahn
    • Gunnar Schulte
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17