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Showing 1–3 of 3 results
Advanced filters: Author: Julien Broseus Clear advanced filters

  • Richter syndrome (RS) is the transformation of chronic lymphocytic leukaemia (CLL) into aggressive lymphoma, in most cases diffuse large B-cell lymphoma (DLBCL). Here, the authors characterize the DNA methylation and transcriptomic profiles of RS samples, find a clonally-related CLL epigenetic imprint, and develop classifiers for “RS-type” de novo DLBCLs.

    • Julien Broséus
    • Sébastien Hergalant
    • Stephan Stilgenbauer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • A combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is a commonly used regimen for patients with Richter transformation (RT), an aggressive lymphoma with a poor prognosis. Here the authors report the results of a phase 2 clinical trial of blinatumomab (an anti-CD3/anti-CD19 bispecific T-cell-engager) after R-CHOP bridging therapy for patients with RT.

    • Romain Guièze
    • Loïc Ysebaert
    • Pierre Feugier
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-8