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Structure of the full-length HCV IRES in solution

The hepatitis C virus RNA genome is translated via an internal ribosome entry site. Pérard et al. present an atomic model of this site, and using molecular dynamics simulations, identify conformational flexibility that may underlie its function during translation initiation.

Julien Pérard
Cédric Leyrat
Marc Jamin
Research19 Mar 2013
Nature Communications

Volume: 4, P: 1-11
Author Correction: Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation

Yohei Morishita
Suze Ma
Brandon I. Morinaka
Amendments and Corrections17 Mar 2025
Nature Chemistry

Volume: 17, P: 624
Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation

Radical SAM (rSAM) and 2-His-1-carboxylate enzymes are known to co-occur in RiPP biosynthetic pathways. Here we show the fusion of these enzymes in a single protein where the rSAM enzyme catalyzes cyclophane formation. The 2-His-1-carboxylate enzymes—termed αKG-HExxH—are α-ketoglutarate non-haem iron enzymes that harbour a distinct fold and catalyse β-hydroxylation.

Yohei Morishita
Suze Ma
Brandon I. Morinaka
Research18 Sept 2024
Nature Chemistry

Volume: 16, P: 1882-1893
Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in Francisella tularensis virulence

Pérard et al. report the structure of Francisella tularensis Fur (FtFur) with its physiological cofactor Fe²⁺, and show that FtFur is important for virulence. This study identifies a promoter-driven tetramer splitting mechanism that may provide insight into future antibiotics development.

J. Pérard
S. Nader
I. Michaud-Soret
ResearchOpen Access17 Jul 2018
Communications Biology

Volume: 1, P: 1-13

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Structure of the full-length HCV IRES in solution

Author Correction: Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation

Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation

Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in Francisella tularensis virulence

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