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Showing 1–4 of 4 results
Advanced filters: Author: Julien P. Limenitakis Clear advanced filters

  • A mouse model of systemic versus mucosal exposure to microbial taxa reveals that the former provokes a flexible B cell response with a diverse immunoglobulin repertoire, whereas the latter generates a more-restricted response.

    • Hai Li
    • Julien P. Limenitakis
    • Andrew J. Macpherson
    Research
    Nature
    Volume: 584, P: 274-278

  • The inner layer of the mucus that covers our intestine is nearly sterile. Here, the authors show in mice that the outer mucus layer constitutes a unique microbial niche hosting bacterial communities with distinct proliferation rates and resource utilization activities.

    • Hai Li
    • Julien P. Limenitakis
    • Andrew J. Macpherson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Virulent pathogens generally induce a stronger mucosal immunity than avirulent strains, but whether the associated inflammation is necessary for this is unclear. Here, using auxotrophic Salmonella enterica, the authors show that virulence factor function determines induction of protective IgA.

    • Simona P. Pfister
    • Olivier P. Schären
    • Siegfried Hapfelmeier
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18