The Elongator complex has been associated with a wide range of cellular processes, including post-transcriptional modification of tRNAs. Structural and biochemical analyses of Elongator proteins 4, 5 and 6 now show that they form a RecA-like hexameric ring that binds tRNAs in a manner regulated by ATP hydrolysis.
- Sebastian Glatt
- Juliette Létoquart
- Christoph W Müller