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Showing 1–12 of 12 results
Advanced filters: Author: Julio F Cordero-Morales Clear advanced filters

  • The K+ channels can display three distinct gating modes. The molecular basis for two of these modes (low open probability and flickery) are now examined by a combination of single-channel recording, crystallography and modeling of mutants in Glu71, revealing that changes in ion and water occupancy in and around the selectivity filter determine modal gating.

    • Sudha Chakrapani
    • Julio F Cordero-Morales
    • Eduardo Perozo
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 67-74

  • Angelman syndrome (AS) is a neurogenetic disorder. Here, the authors found that PIEZO2 activity is reduced in sensory neurons from a mouse model of AS and used a linoleic acid-enriched diet to enhance PIEZO2 function and ameliorate AS-associated gait deficits.

    • Luis O. Romero
    • Rebeca Caires
    • Julio F. Cordero-Morales
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Piezo channels are mechanosensitive and rely on membrane composition to transduce physical stimuli into electrical signals. Here authors analyse the membrane components that modulate Piezo1 function using lipid profiling which shows that fatty acid metabolism can modulate ion channel activity.

    • Luis O. Romero
    • Andrew E. Massey
    • Valeria Vásquez
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • PIEZO2 is a critical component of the mechanism by which innocuous touch causes pain (tactile allodynia). Here, authors find that the dietary fatty acid margaric acid decreases PIEZO2 function in a dose-dependent manner and counteracts neuronal mechanical sensitization by a proalgesic agent.

    • Luis O. Romero
    • Rebeca Caires
    • Valeria Vásquez
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Snakes are notoriously apt at generating 'thermal images' of predators or prey. The underlying physiology has been unclear, although in snakes such as pythons, vipers and boas, infrared signals are initially received by the pit organ. Here it is shown that pit-bearing snakes rely on heat detection by the ion channel TRPA1. This extends the sensory repertoire of the TRPA1 family of proteins, which detect chemical irritants in mammals and thermal variations in insects.

    • Elena O. Gracheva
    • Nicholas T. Ingolia
    • David Julius
    Research
    Nature
    Volume: 464, P: 1006-1011

  • K+ channels can convert between conductive and non-conductive forms through mechanisms that range from flicker transitions (which occur in microseconds) to C-type inactivation (which occurs on millisecond to second timescales). Here, the mechanisms are revealed through which movements of the inner gate of the K+ channel KcsA trigger conformational changes at the selectivity filter, leading to the non-conductive C-type inactivated state.

    • Luis G. Cuello
    • Vishwanath Jogini
    • Eduardo Perozo
    Research
    Nature
    Volume: 466, P: 272-275