Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–21 of 21 results
Advanced filters: Author: Julius B. Lucks Clear advanced filters

  • Allosteric transcription factors (aTFs) are promising tools for environmental and human health monitoring. Here the authors develop a multi-objective, machine learning-guided method to engineer an aTF-based portable diagnostic for environment sensing of lead in drinking water at the legal limit.

    • Brenda M. Wang
    • Nicole Chiang
    • Michael C. Jewett
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14

  • Riboswitches are RNA sensors that allow bacteria to sense and respond to their environment. Here, Bushhouse et al. demonstrate that the sensitivity of several riboswitches can be tuned by manipulating how the riboswitch RNAs fold during transcription.

    • David Z. Bushhouse
    • Jiayu Fu
    • Julius B. Lucks
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • A signal amplification circuit based on recycling nucleic acid inputs with RNA polymerase off-target transcription improves the sensitivity of transcription factor-based cell-free biosensors, achieving 10-fold decreases in limits of detection.

    • Yueyi Li
    • Tyler Lucci
    • Julius B. Lucks
    Research
    Nature Chemical Biology
    Volume: 21, P: 949-958

  • Perceptions of drinking water safety influence how people use and value water. Here, the authors find that 52.3% of adults across 141 countries self-report anticipating harm from drinking water.

    • Joshua D. Miller
    • Chad Staddon
    • Sera L. Young
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Equipping ROSALIND, a cell-free biosensing platform, with information processing circuits based on toehold-mediated DNA strand displacement enhances sensor performance and enables logic gate computation.

    • Jaeyoung K. Jung
    • Chloé M. Archuleta
    • Julius B. Lucks
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 385-393

  • RNA has been used in a variety of synthetic biology circuits but never as a transcriptional activator. Two design strategies using synthetic and natural sequences now lead to RNA activators, enabling RNA-only logic gates.

    • James Chappell
    • Melissa K Takahashi
    • Julius B Lucks
    Research
    Nature Chemical Biology
    Volume: 11, P: 214-220

  • The authors characterize the cotranscriptional folding of the Clostridium beijerinckii pfl ZTP riboswitch in response to its ligand ZMP, and reveal that an internal RNA strand displacement and riboswitch sequence play important roles in the process.

    • Eric J. Strobel
    • Luyi Cheng
    • Julius B. Lucks
    Research
    Nature Chemical Biology
    Volume: 15, P: 1067-1076

  • Automated 3D design produces rapid and near-atomically accurate predictions of RNA tertiary structure as well as the ability to generate complex RNA machines such as functional single-stranded tethered ribosomes, and enhancement of the binding properties of small-molecule RNA aptamers.

    • Joseph D. Yesselman
    • Daniel Eiler
    • Rhiju Das
    Research
    Nature Nanotechnology
    Volume: 14, P: 866-873

  • The structural basis of RNA-based gene control offers the possibility of de novo design. Here the authors present a computational design approach for Small Transcription Activating RNAs a bacterial RNA regulator that allows for versatile and dynamic control of genes, pathways and genetic circuits.

    • James Chappell
    • Alexandra Westbrook
    • Julius B. Lucks
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Antisense RNA sequences are attractive 'parts' for use as regulatory devices in synthetic biology applications. Synthesis and testing of an RNA library specific to the translation initiation region now allows analysis and forward design of these sequences, leading to a family of mutually orthogonal regulators.

    • Vivek K Mutalik
    • Lei Qi
    • Adam P Arkin
    Research
    Nature Chemical Biology
    Volume: 8, P: 447-454

  • RNAs perform diverse cellular functions that are mediated at least in part by their structure. However, how RNA structure changes throughout the RNA lifecycle and how these changes affect RNA function remain incompletely understood. A detailed in vivo characterization of RNA structure in various cellular subcompartments now provides insights into how RNA structural changes influence translation, RNA decay, protein binding and RNA modification.

    • Angela M Yu
    • Julius B. Lucks
    News & Views
    Nature Structural & Molecular Biology
    Volume: 26, P: 256-257

  • Applying SHAPE-seq to analyze cotranscriptional folding of the B. cereus crcB fluoride riboswitch at nucleotide resolution shows that the folding pathway undergoes a ligand-dependent bifurcation that influences terminator formation via coordinated structural transitions.

    • Kyle E Watters
    • Eric J Strobel
    • Julius B Lucks
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 1124-1131

  • Developing biotechnologies to address society’s challenges requires integrating concepts across disciplines, posing challenges to educating students with diverse expertise. In this Perspective the authors create a framework for synthetic biology training that deconstructs biotechnologies across spatial scales.

    • Ashty S. Karim
    • Dylan M. Brown
    • Julius B. Lucks
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • High-throughput sequencing technology is enabling the structures of RNA to be determined on an unprecedented scale, providing insights into the relationship between the structures adopted by RNAs and the functions they perform in the cell.

    • Eric J. Strobel
    • Angela M Yu
    • Julius B. Lucks
    Reviews
    Nature Reviews Genetics
    Volume: 19, P: 615-634