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Showing 1–12 of 12 results
Advanced filters: Author: Julius Brennecke Clear advanced filters

  • The ATPase UAP56 acts as an ATP-gated molecular switch that directs mRNA ribonucleoprotein complexes from TREX to nuclear-pore-complex-anchored TREX-2 complexes for mRNA export from the nucleus.

    • Ulrich Hohmann
    • Max Graf
    • Clemens Plaschka
    ResearchOpen Access
    Nature
    Volume: 649, P: 1042-1050

  • Transcription of Drosophila PIWI-interacting RNA (piRNA) clusters is enforced through RNA polymerase II pre-initiation complex formation within repressive heterochromatin, accomplished through the transcription factor IIA subunit paralogue Moonshiner.

    • Peter Refsing Andersen
    • Laszlo Tirian
    • Julius Brennecke
    Research
    Nature
    Volume: 549, P: 54-59

  • Drosophila have two pathways for PIWI-interacting RNA (piRNA) 3′-end formation—depending on which pathway is used, piRNA biogenesis is directed towards either cytoplasmic or nuclear PIWI protein effectors, which balances post-transcriptional versus transcriptional transposon silencing.

    • Rippei Hayashi
    • Jakob Schnabl
    • Julius Brennecke
    Research
    Nature
    Volume: 539, P: 588-592

  • Identification of SFiNX, a complex of Nxf2–Nxt1, a variant of the mRNA export receptor Nxf1–Nxt1 and the Piwi-associated protein Panoramix, demonstrates an RNA export independent role for Nxf2 in piRNA-guided cotranscriptional transposon silencing.

    • Julia Batki
    • Jakob Schnabl
    • Julius Brennecke
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 720-731

  • Short hairpin RNAs, expressed from microRNA scaffold–containing vectors, efficiently silence gene expression in female germ cells as well as somatic cells in the fly. A genome-wide resource is being developed.

    • Jian-Quan Ni
    • Rui Zhou
    • Norbert Perrimon
    Research
    Nature Methods
    Volume: 8, P: 405-407

  • In Caenorhabditis tropicalis, selective expression of genetic alleles from one parent but not the other can arise from maternally inherited small transcripts acting via the PIWI-interacting RNA host defence pathway.

    • Pinelopi Pliota
    • Hana Marvanova
    • Alejandro Burga
    ResearchOpen Access
    Nature
    Volume: 628, P: 122-129

  • This paper identifies a class of small RNAs in fly: endogenous siRNAs (endo-siRNAs). These RNAs are present in both somatic and gonadal cells, and their processing is different than that of miRNAs or piRNAs.

    • Benjamin Czech
    • Colin D. Malone
    • Julius Brennecke
    Research
    Nature
    Volume: 453, P: 798-802