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Showing 1–9 of 9 results
Advanced filters: Author: Jun Wei Pek Clear advanced filters
  • How phosphorylation mediated by Insulin/IGF-1 Signaling kinases regulates lifespan remains unclear. Here the authors perform a large-scale quantitative phosphoproteomic analysis of wildtype and IIS mutant C. elegans strains to reveal detailed functional insights into longevity.

    • Wen-Jun Li
    • Chen-Wei Wang
    • Meng-Qiu Dong
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality behaviours. Here we report a simulation of how improvements in four risk factors, namely smoking, alcohol use, physical activity and diet, could affect mortality. We show that in the ideal scenario, that is, all people who currently smokers quit smoking, excessive alcohol userswas reduced to moderate intake, people under 65 increased moderate physical activity by one hour and those aged 65 and older increased by half an hour per day, and all participants ate 200 g more fresh fruits and 50 g more fish/seafood per day, life expectancy at age 30 would increase by 4.83 and 5.39 years for men and women, respectively. In a more moderate risk reduction scenario referred to as the practical scenario, where improvements in each lifestyle factor were approximately halved, the gains in life expectancy at age 30 could be half those of the ideal scenario. However, the validity of these estimates in practise may be influenced by population-wide adherence to lifestyle recommendations. Our findings suggest that the current policy targets set by the Healthy China Initiative could be adjusted dynamically, and a greater increase in life expectancy would be achieved.

    • Qiufen Sun
    • Liyun Zhao
    • Chan Qu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Stable introns were serendipitously discovered just over a decade ago.

    • Jun Wei Pek
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 453
  • Observational analyses from the China Kadoorie Biobank found that alcohol consumption was associated with higher risks of 61 diseases in Chinese men, with most of these associations confirmed by genetic analyses.

    • Pek Kei Im
    • Neil Wright
    • Xiaoyi Zhang
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1476-1486
  • Stable intronic sequence RNAs (sisRNAs) are by-products of splicing from introns with roles in embryonic development in Drosophila. Here, the authors show that the RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.

    • Jing Ting Wong
    • Farzanah Akhbar
    • Jun Wei Pek
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12
  • Alternative splicing of eukaryotic messenger RNA transcripts often leads to the production of several mature RNAs — including linear RNAs and circular RNAs (circRNAs) — from a single gene locus. The names given to circRNAs are often ambiguous and lack consistency across studies. This Comment calls on the community to embrace a common nomenclature for naming circRNAs to ensure clarity and reproducibility.

    • Ling-Ling Chen
    • Albrecht Bindereif
    • Fangqing Zhao
    Comments & Opinion
    Nature Cell Biology
    Volume: 25, P: 1-5