C−H bond functionalization is widely used in chemical synthesis but achieving regio- and stereoselectivity is still challenging. Here, the authors report the mechanism of three Fe(II)/α-ketoglutarate-dependent dioxygenases in bicyclomycin synthesis, which depicts the natural strategy to sequentially hydroxylate specific C–H bonds of similar substrates (cyclodipeptides)
- Lian Wu
- Jun-Bin He
- Jiahai Zhou
