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Mycobacterium tuberculosis IDH-PPARγ interaction suppresses GPX4 to drive macrophage ferroptosis and sustain persistent infection

Mycobacterium tuberculosis (M.tb) actively intervenes in host cell lipid metabolism during infection. Here the authors show that M.tb modulates the IDH-PPARγ axis to drive ferroptosis and bacterial persistence in macrophages.

Wenyuan Pu
Ximeng Zhang
Zhiqiang Huang
ResearchOpen Access08 Jun 2026
Nature Communications

P: 1-23
Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis

Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation. This study shows that gut microbiota dysbiosis disrupts keratinocyte lipid metabolism via the bile acid–FXR–NQO1 pathway, supporting microbiota-targeted therapeutic approaches.

Panpan Lian
Renwei Lu
Zhiqiang Huang
ResearchOpen Access18 May 2026
Nature Communications

P: 1-19
Enhanced confocal microscopy with physics-guided autoencoders via synthetic noise modeling

Zaheer Ahmad
Junaid Shabeer
Wazir Muhammad
ResearchOpen Access07 Jan 2026
Scientific Reports

Volume: 16, P: 1-14
S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis

Panpan Lian
Li Li
Hongwei Wang
ResearchOpen Access20 Jan 2025
Cell Death & Disease

Volume: 16, P: 1-14
Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling

Chujun Ma
Chaode Gu
Zhonglan Su
ResearchOpen Access25 Nov 2023
Cell Death & Disease

Volume: 14, P: 1-12
Alpha-7 nicotinic acetylcholine receptor agonist alleviates psoriasis-like inflammation through inhibition of the STAT3 and NF-κB signaling pathway

Yiwen Chen
Panpan Lian
Zhonglan Su
ResearchOpen Access30 Mar 2022
Cell Death Discovery

Volume: 8, P: 1-14
An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models

Mengyuan Niu
Li Li
Hongwei Wang
ResearchOpen Access26 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-12

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Mycobacterium tuberculosis IDH-PPARγ interaction suppresses GPX4 to drive macrophage ferroptosis and sustain persistent infection

Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis

Enhanced confocal microscopy with physics-guided autoencoders via synthetic noise modeling

S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis

Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling

Alpha-7 nicotinic acetylcholine receptor agonist alleviates psoriasis-like inflammation through inhibition of the STAT3 and NF-κB signaling pathway

An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models

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