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Showing 1–5 of 5 results
Advanced filters: Author: Jungeui Hong Clear advanced filters

  • This study uses single-cell DNA sequencing to analyze genomic evolution in pancreatic cancer using a cohort of multiregionally and longitudinally sampled patients’ tissues across various clinical contexts.

    • Haochen Zhang
    • Palash Sashittal
    • Christine A. Iacobuzio-Donahue
    ResearchOpen Access
    Nature Genetics
    P: 1-11

  • Implementing high-throughput single-cell DNA sequencing for the study of solid tumours has been challenging. Here, the authors present an optimised approach for snap-frozen tissue single nuclei extraction and DNA sequencing, which can be applied to study pancreatic ductal adenocarcinoma evolution and heterogeneity.

    • Haochen Zhang
    • Elias-Ramzey Karnoub
    • Christine A. Iacobuzio-Donahue
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Christine Iacobuzio-Donahue and colleagues report a detailed analysis of whole-genome sequencing data from primary and metastatic tumors in four patients with pancreatic cancer. They find that in each patient primary tumors and metastases have identical mutations in known driver genes.

    • Alvin P Makohon-Moore
    • Ming Zhang
    • Christine A Iacobuzio-Donahue
    Research
    Nature Genetics
    Volume: 49, P: 358-366

  • Vast developments are being made within the field of pancreatic cancer genomics. This Review discusses the wide-ranging and most current research with the goal of integrating this information into a unifying description of the life history of pancreatic cancer.

    • Akimasa Hayashi
    • Jungeui Hong
    • Christine A. Iacobuzio-Donahue
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 18, P: 469-481