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Nature Communications (2)

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Advanced filters: Author: Junmeng Zhu Clear advanced filters

Engineered vesicles enhance oral antibiotic absorption in proximal small intestine and mitigate gut dysbiosis

In this work, authors present a biohybrid delivery system aimed at overcoming low oral bioavailability and antibiotic-induced dysbiosis by enabling efficient antibiotic transport in the proximal small intestine.

Yinglan Yu
Yongfeng Xu
Lei Luo
ResearchOpen Access25 Dec 2025
Nature Communications

Volume: 17, P: 1-14
Engineered Lactococcus lactis secreting Flt3L and OX40 ligand for in situ vaccination-based cancer immunotherapy

The probiotic Lactococcus lactis has been used for the delivery of therapeutic molecules. Here the authors engineer Lactococcus lactis to express a fusion protein of Flt3L and OX40 ligand, eliciting anti-tumor immune response in preclinical cancer models.

Junmeng Zhu
Yaohua Ke
Baorui Liu
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-18

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Engineered vesicles enhance oral antibiotic absorption in proximal small intestine and mitigate gut dysbiosis

Engineered Lactococcus lactis secreting Flt3L and OX40 ligand for in situ vaccination-based cancer immunotherapy

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