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Nature Communications (2)
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Showing 1–7 of 7 results

Advanced filters: Author: Junming Guan Clear advanced filters

Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage

Glucagon-like peptide 1 (GLP1) is processed and cleaved from proglucagon to stimulate insulin secretion. Here, authors show that Nogo-B interacts with proglucagon to retain it on the ER, thereby inhibiting PCSK1-mediated cleavage of proglucagon and secretion of GLP1.

Ke Gong
Chao Xue
Yajun Duan
ResearchOpen Access10 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Publisher Correction: Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage

Ke Gong
Chao Xue
Yajun Duan
Amendments and CorrectionsOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1
Family-based genome-wide association study designs for increased power and robustness

This study develops family-based genome-wide association study methods that maximize power in homogeneous samples through inclusion of singletons and in diverse samples by using all available parental genotypes.

Junming Guan
Tammy Tan
Alexander Strudwick Young
ResearchOpen Access10 Mar 2025
Nature Genetics

Volume: 57, P: 1044-1052
Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity

Hu et al. study the role of hexokinase 2 in microglial metabolism and function, and show its dual role under physiological and pathological conditions in a mouse model of stroke-induced neuroinflammation

Yaling Hu
Kelei Cao
Zhihua Gao
Research19 Dec 2022
Nature Metabolism

Volume: 4, P: 1756-1774
Predicting the age of ancient trees and the factors influencing their growth of Lychee trees (Litchi chinensis)

Junming Zheng
Yashan Chen
Ying Xiao
ResearchOpen Access09 Jun 2025
npj Heritage Science

Volume: 13, P: 1-12
Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis

Peiran Feng
Quanli Yang
Meixiang Yang
Research08 Aug 2024
Cell Death & Differentiation

Volume: 31, P: 1519-1533
Responses of corn physiology and yield to six agricultural practices over three years in middle Tennessee

Chih-Li Yu
Dafeng Hui
Sam Dennis
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-9