Susceptibility of Nasopharyngeal carcinoma (NPC), associated with Epstein-Barr virus infection, is linked with HLA gene region with mechanisms unclear. The authors here show that the high-risk EBV subtype BALF2 upregulates HLA-DP, leading to CD8+ T cell exhaustion, and combined anti-LAG-3 and anti-PD-1 therapy improves anti-cancer efficacy.
- Yi Meng
- Qian Wang
- Wei Xiong
