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Showing 1–6 of 6 results
Advanced filters: Author: Jussi Hepojoki Clear advanced filters

  • The POLG1 mutation p.W748S, which is associated with mitochondrial recessive ataxia syndrome, dampens innate immune responses by compromising mtDNA replisome stability, and this explains why a viral infection can trigger the development of the disease and contribute to its variable clinical manifestation.

    • Yilin Kang
    • Jussi Hepojoki
    • Anu Suomalainen
    ResearchOpen Access
    Nature
    Volume: 628, P: 844-853

  • Emerging SARS-CoV-2 variants contain mutations in the spike protein that may affect vaccine efficacy. Here, Jalkanen et al. show, using sera from 180 BNT162b2-vaccinated health care workers, that neutralization of SARS-CoV2 variant B.1.1.7 is not affected, while neutralization of B.1.351 variant is five-fold reduced.

    • Pinja Jalkanen
    • Pekka Kolehmainen
    • Ilkka Julkunen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Vaheri and colleagues discuss the molecular and cell biology of hantavirus infection and provide an overview of the virus-induced and immune-mediated pathology caused by this virus family in humans.

    • Antti Vaheri
    • Tomas Strandin
    • Jukka Mustonen
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 539-550