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Advanced filters: Author: Justin D. Trombley Clear advanced filters

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

The use of functional genomics in primary immune cells has been limited by inefficient vector delivery and risk of perturbing cell states. Here the authors present CHimeric IMmune Editing (CHIME) for in vivo evaluation of gene function and pooled screening approaches.

Martin W. LaFleur
Thao H. Nguyen
Arlene H. Sharpe
ResearchOpen Access10 Apr 2019
Nature Communications

Volume: 10, P: 1-10
Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling

Fibroblastic reticular cells (FRCs) are dynamic regulators of lymphoid tissue structure. Turley and colleagues show FRCs also support activated T cells by producing IL-6, which confers an advantage to CD8+ T cell memory responses.

Flavian D. Brown
Debattama R. Sen
Shannon J. Turley
Research21 Oct 2019
Nature Immunology

Volume: 20, P: 1668-1680
LandScan Global 30 Arcsecond Annual Global Gridded Population Datasets from 2000 to 2022

Viswadeep Lebakula
Kelly Sims
Eddie Bright
ResearchOpen Access24 Mar 2025
Scientific Data

Volume: 12, P: 1-16