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Showing 1–4 of 4 results

Advanced filters: Author: Justin M. Quiles Clear advanced filters

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

Mitochondrial quality control is critical for cellular homeostasis and survival. Here, the authors identify that defective mitochondria can be eliminated via secretion in large extracellular vesicles when internal lysosomal degradation is compromised.

Wenjing Liang
Shakti Sagar
Åsa B. Gustafsson
ResearchOpen Access18 Aug 2023
Nature Communications

Volume: 14, P: 1-18
The role of mitochondrial fission in cardiovascular health and disease

In this Review, Quiles and Gustafsson compare the physiological and pathophysiological roles of mitochondrial fission and discuss the therapeutic potential of preventing excessive mitochondrial fission in the heart and vasculature.

Justin M. Quiles
Åsa B. Gustafsson
Reviews06 May 2022
Nature Reviews Cardiology

Volume: 19, P: 723-736
Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress

Justin M. Quiles
Mark E. Pepin
Namakkal S. Rajasekaran
ResearchOpen Access07 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Nuclear Parkin Activates the ERRα Transcriptional Program and Drives Widespread Changes in Gene Expression Following Hypoxia

Sarah E. Shires
Justin M. Quiles
Åsa B. Gustafsson
ResearchOpen Access22 May 2020
Scientific Reports

Volume: 10, P: 1-15