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Showing 1–7 of 7 results
Advanced filters: Author: Justin Rhoades Clear advanced filters

  • DNA methylation from cell-free DNA (cfDNA) can be profiled using whole genome bisulfite sequencing (WGBS). Here, the authors develop a computational method, FinaleMe, that predicts DNA methylation and tissues of-origin in cfDNA and validate its performance using paired deep and shallow-coverage whole-genome sequencing (WGS) and WGBS data.

    • Yaping Liu
    • Sarah C. Reed
    • Manolis Kellis
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Conducting a simulated turtlegrass herbivory experiment across 650 experimental plots and 13 seagrass meadows, the authors show that the negative effects of herbivory increase with latitude, driven by low levels of light insolation at high latitudes.

    • Justin E. Campbell
    • O. Kennedy Rhoades
    • William L. Wied
    Research
    Nature Ecology & Evolution
    Volume: 8, P: 663-675

  • Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole-exome sequencing is concordant with metastatic tumour whole-exome sequencing.

    • Viktor A. Adalsteinsson
    • Gavin Ha
    • Matthew Meyerson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Concatenating Original Duplex for Error Correction (CODEC) is a method that concatenates both strands of each DNA duplex to enable highly sensitive mutation detection in a range of analytes with fewer reads and lower error rates than current methods.

    • Jin H. Bae
    • Ruolin Liu
    • Viktor A. Adalsteinsson
    ResearchOpen Access
    Nature Genetics
    Volume: 55, P: 871-879