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Showing 1–5 of 5 results
Advanced filters: Author: Jutta Jalkanen Clear advanced filters

  • Single-cell studies of human white adipose tissue (WAT) provide insights into the specialized cell types in the tissue. Here the authors combine publicly available and newly generated high-resolution and bulk transcriptomic results from multiple human datasets to provide a comprehensive cellular map of white adipose tissue.

    • Lucas Massier
    • Jutta Jalkanen
    • Niklas Mejhert
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Many survivors of COVID-19 experience persistent symptoms, continuing beyond three months from the onset of infection. In this study, authors investigate the effect of remdesivir on recovery and long-COVID-19 symptoms, as well as quality of life and other symptom outcomes, in the 1-year follow-up of a randomised trial.

    • Olli P. O. Nevalainen
    • Saana Horstia
    • Kari A. O. Tikkinen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-6

  • Lecoutre, Maqdasy and Rizo-Roca show that whole-body pharmacological inhibition or adipocyte-specific deletion of glutaminase in mice activates thermogenesis in inguinal adipocytes and promotes metabolic health. They also link decreased plasma and adipose tissue glutamine-to-glutamate ratios to insulin resistance in humans with obesity.

    • Simon Lecoutre
    • Salwan Maqdasy
    • Mikael Rydén
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 1329-1346

  • Adipocyte-expressed long non-coding RNAs (lncRNAs) have been shown to regulate the transcription of genes involved in lipid metabolism. Here the authors describe a human adipocyte-specific lncRNA, ADIPINT, which regulates lipid metabolism in white adipocytes in part through its interaction with the metabolic enzyme pyruvate carboxylase.

    • Alastair G. Kerr
    • Zuoneng Wang
    • Hui Gao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • In this Review, the authors present a roadmap towards achieving consensus on development, analysis and interpretation of single-cell transcriptomics data in adipose tissue, including discussion of roadblocks, best practices and ideal cell-type markers for annotation of adipose tissue cell types in mice and humans.

    • Anne Loft
    • Margo P. Emont
    • Evan D. Rosen
    Reviews
    Nature Metabolism
    Volume: 7, P: 875-894