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Nature Genetics (1)

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Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma

Marker-based CRISPR screens in pancreatic cancer cells followed by functional validation highlight a role for MED12 in bridging ΔNp63 and components of the Mediator family. This interaction helps drive basal cell identity in pancreatic ductal adenocarcinoma.

Diogo Maia-Silva
Patrick J. Cunniff
Christopher R. Vakoc
Research17 Jun 2024
Nature Genetics

Volume: 56, P: 1377-1385

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Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma

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