Nature Search

Thermal spectrometer for superconducting circuits

The authors demonstrate a simple direct-current-measurement characterization of a quarter-wavelength superconducting coplanar waveguide resonator using an on-chip bolometer. This approach offers simpler experimental instrumentation and much larger frequency range of operation compared to traditional RF techniques.

Christoforus Dimas Satrya
Yu-Cheng Chang
Jukka P. Pekola
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-7
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Genome-wide association analyses of two oral glucose tolerance test-derived measures of postprandial insulin resistance discover ten new loci. Functional characterization identifies nine candidate genes implicated in the regulation of GLUT4.

Alice Williamson
Dougall M. Norris
Claudia Langenberg
Research08 Jun 2023
Nature Genetics

Volume: 55, P: 973-983
Enhanced excision of O⁶-alkylguanine in rat liver by pretreatment with acetylaminofluorene

J. E. CLEAVER
W. K. KAUFMANN
Research27 Mar 1980
Nature

Volume: 284, P: 378
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
Discovery and engineering of the antibody response to a prominent skin commensal

Staphylococcus epidermidis induces a potent, durable and specific antibody response that is conserved in humans and non-human primates, and which could be redirected against pathogens as a new form of topical vaccination.

Djenet Bousbaine
Katherine D. Bauman
Michael A. Fischbach
Research11 Dec 2024
Nature

Volume: 638, P: 1054-1064
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000–2018

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

Natalia V. Bhattacharjee
Lauren E. Schaeffer
Simon I. Hay
ResearchOpen Access03 Jun 2021
Nature Human Behaviour

Volume: 5, P: 1027-1045
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.

Vasiliki Lagou
Reedik Mägi
Inga Prokopenko
ResearchOpen Access05 Jan 2021
Nature Communications

Volume: 12, P: 1-18
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

Anubha Mahajan
Min Jin Go
Andrew P Morris
Research09 Feb 2014
Nature Genetics

Volume: 46, P: 234-244
The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection

William Foulsham
Sharad K. Mittal
Reza Dana
ResearchOpen Access13 Jun 2019
Scientific Reports

Volume: 9, P: 1-8
RNAi modulation of placental sFLT1 for the treatment of preeclampsia

Preeclampsia, a hypertension condition with no approved therapies, is treated in monkeys by gene silencing in the placenta.

Anton A Turanov
Agnes Lo
Anastasia Khvorova
Research19 Nov 2018
Nature Biotechnology

Volume: 36, P: 1164-1173
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

Anne Hinks and colleagues identify 14 new susceptibility loci for juvenile idiopathic arthritis through targeted analyses of genomic regions implicated in immune function. Their study implicates several pathways, including IL-2 signaling, in the pathogenesis of this common childhood autoimmune disease.

Anne Hinks
Joanna Cobb
Susan D Thompson
Research21 Apr 2013
Nature Genetics

Volume: 45, P: 664-669
Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

Resistance of gRNA to ubiquitous ribonucleases is required for CRISPR-Cas9-based therapeutics. Here, the authors explore chemical modifications at all positions of the crRNA guide and tracrRNA cofactor, and identify modified versions that are more potent and stable than their unmodified counterparts in editing human cells.

Aamir Mir
Julia F. Alterman
Erik J. Sontheimer
ResearchOpen Access06 Jul 2018
Nature Communications

Volume: 9, P: 1-9
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Infection with Omicron after vaccination produces cross-neutralizing antibodies to other variants of concern, whereas this induces a limited response to non-Omicron variants in unvaccinated individuals.

Rahul K. Suryawanshi
Irene P. Chen
Melanie Ott
ResearchOpen Access18 May 2022
Nature

Volume: 607, P: 351-355
Mapping cis- and trans-regulatory effects across multiple tissues in twins

The MuTHER Consortium reports an analysis of the genetics of gene expression in three tissues from approximately 850 mono- and dizygotic twins. They systematically dissect cis and trans genetic effects and estimate non-genetic effects on gene expression.

Elin Grundberg
Kerrin S Small
Tim D Spector
Research02 Sept 2012
Nature Genetics

Volume: 44, P: 1084-1089
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

Genome-wide association analyses of DNA methylation in peripheral blood from 3,799 Europeans and 3,195 South Asians identify unique SNP–CpG associations (meQTL), providing insights into molecular mechanisms and the potential links to phenotypic variation.

Johann S. Hawe
Rory Wilson
John C. Chambers
Research03 Jan 2022
Nature Genetics

Volume: 54, P: 18-29
An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12

Chen Keasar
Liam J. McGuffin
Silvia N. Crivelli
ResearchOpen Access02 Jul 2018
Scientific Reports

Volume: 8, P: 1-18
Differential methylation of the TRPA1 promoter in pain sensitivity

Genetically identical twins provide a valuable resource to identify epigenetic factors associated with complex traits. Here the authors adopt this approach and find that differential methylation of the pain gene TRPA1is associated with pain sensitivity in humans.

J.T. Bell
A.K. Loomis
T.D. Spector
ResearchOpen Access04 Feb 2014
Nature Communications

Volume: 5, P: 1-11
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

John Chambers and colleagues report a genome-wide association study for type 2 diabetes in individuals of south Asian ancestry. They identify six loci newly associated with type 2 diabetes.

Jaspal S Kooner
Danish Saleheen
John C Chambers
Research28 Aug 2011
Nature Genetics

Volume: 43, P: 984-989
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Currently, genome-wide methylation studies are limited to using targeted arrays or enrichment to assess large sample sizes. Here, Allum et al. demonstrate MethylC-Capture Sequencing, a cost-effective method for investigating genetic and epigenetic variation.

Fiona Allum
Xiaojian Shao
Elin Grundberg
ResearchOpen Access29 May 2015
Nature Communications

Volume: 6, P: 1-12
Clostridium sporogenes uses reductive Stickland metabolism in the gut to generate ATP and produce circulating metabolites

The gut bacterium Clostridium sporogenes uses reductive Stickland reactions for energy and consequently produces metabolites that circulate in the host.

Yuanyuan Liu
Haoqing Chen
Dylan Dodd
Research02 May 2022
Nature Microbiology

Volume: 7, P: 695-706
Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Fiona Allum
Xiaojian Shao
Elin Grundberg
Amendments and Corrections29 Jul 2015
Nature Communications

Volume: 6, P: 1
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

The next step after sequencing a genome is to figure out how the cell actually uses it as an instruction manual. A large international consortium has examined 1% of the genome for what part is transcribed, where proteins are bound, what the chromatin structure looks like, and how the sequence compares to that of other organisms.

Ewan Birney
John A. Stamatoyannopoulos
Pieter J. de Jong
Research14 Jun 2007
Nature

Volume: 447, P: 799-816
Genetic evidence of assortative mating in humans

Using whole-genome data for single-nucleotide polymorphism and results from genome-wide association studies, the authors show that people’s preference for pairing with those with similar phenotypic traits has genetic causes and consequences.

Matthew R. Robinson
Aaron Kleinman
Peter M. Visscher
Research09 Jan 2017
Nature Human Behaviour

Volume: 1, P: 1-13
The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females

R C Chiaroni-Clarke
Y R Li
J A Ellis
Research20 Aug 2015
Genes & Immunity

Volume: 16, P: 495-498
E pluribus unum interpretable convolutional neural networks

George Dimas
Eirini Cholopoulou
Dimitris K. Iakovidis
ResearchOpen Access14 Jul 2023
Scientific Reports

Volume: 13, P: 1-22
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Molecular detection and genetic characterization of hemotropic mycoplasmas in goats and fleas from Thailand

Muhammad Shair Zaman Ghauri
Samiullah Soomro
Morakot Kaewthamasorn
ResearchOpen Access29 Nov 2024
Scientific Reports

Volume: 14, P: 1-14
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Vasiliki Lagou
Reedik Mägi
Inga Prokopenko
Amendments and CorrectionsOpen Access08 Feb 2021
Nature Communications

Volume: 12, P: 1-2
c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia

E D Lagadinou
P G Ziros
N C Zoumbos
Research24 Jul 2008
Leukemia

Volume: 22, P: 1899-1908

Search

Thermal spectrometer for superconducting circuits

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Enhanced excision of O⁶-alkylguanine in rat liver by pretreatment with acetylaminofluorene

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Discovery and engineering of the antibody response to a prominent skin commensal

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Mapping inequalities in exclusive breastfeeding in low- and middle-income countries, 2000–2018

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection

RNAi modulation of placental sFLT1 for the treatment of preeclampsia

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

Mapping cis- and trans-regulatory effects across multiple tissues in twins

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

An analysis and evaluation of the WeFold collaborative for protein structure prediction and its pipelines in CASP11 and CASP12

Differential methylation of the TRPA1 promoter in pain sensitivity

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Clostridium sporogenes uses reductive Stickland metabolism in the gut to generate ATP and produce circulating metabolites

Erratum: Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Genetic evidence of assortative mating in humans

The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females

E pluribus unum interpretable convolutional neural networks

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Molecular detection and genetic characterization of hemotropic mycoplasmas in goats and fleas from Thailand

Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

c-Jun N-terminal kinase activation failure is a new mechanism of anthracycline resistance in acute myeloid leukemia

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