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Showing 1–3 of 3 results

Advanced filters: Author: K J Hamblett Clear advanced filters

Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

Puurunen et al. demonstrate the safety and tolerability in patients with phenylketonuria of a genetically modified strain of E. coli encoding metabolic enzymes to metabolize phenylalanine to non-toxic metabolites.

Marja K. Puurunen
Jerry Vockley
Aoife M. Brennan
Research22 Jul 2021
Nature Metabolism

Volume: 3, P: 1125-1132
Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis

Michael Bamshad and colleagues report an exome sequencing study of extreme phenotypes to identify genetic variants that modify the risk for chronic Pseudomonas aeruginosa airway infection in individuals with cystic fibrosis.

Mary J Emond
Tin Louie
Michael J Bamshad
Research08 Jul 2012
Nature Genetics

Volume: 44, P: 886-889
Signaling via the anti-CD30 mAb SGN-30 sensitizes Hodgkin's disease cells to conventional chemotherapeutics

C G Cerveny
C-L Law
A F Wahl
Research28 Jul 2005
Leukemia

Volume: 19, P: 1648-1655