Lewy pathology (LP) and neuronal death in clinical Parkinson disease (cPD) have been attributed to the simple spread of misfolded α-synuclein. Surmeieret al. show that the pattern of pathology in cPD is not consistent with this simple model, suggesting that cell-autonomous factors also contribute to pathogenesis.
- D. James Surmeier
- José A. Obeso
- Glenda M. Halliday