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Author Correction: tRNA tracking for direct measurements of protein synthesis kinetics in live cells

Ivan L. Volkov
Martin Lindén
Magnus Johansson
Amendments and Corrections05 Apr 2019
Nature Chemical Biology

Volume: 15, P: 757
tRNA tracking for direct measurements of protein synthesis kinetics in live cells

Combination of single-molecule tracking experiments and machine-learning approaches to monitor diffusional state transitions between ribosome-bound and free tRNAs allows codon resolution measurements of translation kinetics.

Ivan L. Volkov
Martin Lindén
Magnus Johansson
Research16 May 2018
Nature Chemical Biology

Volume: 14, P: 618-626
2′-O-methylation in mRNA disrupts tRNA decoding during translation elongation

2′-O-methylation within mRNA coding regions sterically perturbs interactions of ribosomal-monitoring bases with cognate codon–anticodon helices, leading to excessive rejection of cognate aminoacylated tRNAs during initial selection and proofreading.

Junhong Choi
Gabriele Indrisiunaite
Joseph D. Puglisi
Research19 Feb 2018
Nature Structural & Molecular Biology

Volume: 25, P: 208-216
N⁶-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics

Methylation of adenosine within mRNA coding regions delays tRNA accommodation during translation and thus changes translation dynamics, which might influence protein folding.

Junhong Choi
Ka-Weng Ieong
Joseph D Puglisi
Research11 Jan 2016
Nature Structural & Molecular Biology

Volume: 23, P: 110-115