The oral delivery of nano-drug delivery systems (Nano-DDS) remains challenging. Here the authors construct core–shell mesoporous silica nanoparticles with virus-like nanospikes and demonstrate the versatility of these nanoparticles as Nano-DDS to achieve efficient oral drug delivery by mimicking structural feature, chiral recognition, and gene encapsulation of viruses.
- Zhentao Sang
- Lu Xu
- Heran Li
