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Showing 1–8 of 8 results
Advanced filters: Author: Kaitlyn Hess Clear advanced filters

  • The number of known high-oxidation-state transuranic compounds remains limited, and these typically feature high coordination numbers and/or multiply-bonded donor atoms. Now, a tetrahedral, pentavalent neptunium complex supported by four monoanionic ligands has been isolated and characterized. This complex is stable in the solid state and undergoes a proton-coupled electron transfer reaction in solution.

    • Julie E. Niklas
    • Kaitlyn S. Otte
    • Henry S. La Pierre
    Research
    Nature Chemistry
    Volume: 16, P: 1490-1495

  • Self-assembly of small drugs with organic dyes represents a facile route to synthesize nanoparticles with high drug-loading capability. Here the authors combine a machine learning approach with high-throughput experimental validation to identify which combinations of drugs and excipient lead to successful nanoparticle formation and characterize the therapeutic efficacy of two of them in vitro and in animal models.

    • Daniel Reker
    • Yulia Rybakova
    • Giovanni Traverso
    Research
    Nature Nanotechnology
    Volume: 16, P: 725-733

  • Off-target effects in CRISPR screens for essential regulatory elements have not been systematically evaluated. Here the authors find Cas9 nuclease, CRISPRi/a each have distinct off-target effects, and that these can be accurately identified and removed using the GuideScan sgRNA specificity score.

    • Josh Tycko
    • Michael Wainberg
    • Michael C. Bassik
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14