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Showing 1–4 of 4 results
Advanced filters: Author: Kalina Andreeva Clear advanced filters

  • Here, the authors report recent updates to the ENCODE data portal including a redesigned home page, an improved search interface, custom-designed pages highlighting biologically related datasets and an enhanced cart interface for data visualisation plus user-friendly data download options.

    • Meenakshi S. Kagda
    • Bonita Lam
    • Benjamin C. Hitz
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • The advent of immunotherapy has revolutionised cancer therapeutics, but its application in the context of pancreatic ductal adenocarcinoma has been limited. Here authors explore the effect of innate trained responses to fungal β-glucan and assess its effect in a murine model of pancreatic ductal adenocarcinoma where they observe reduced tumour burden and enhanced survival.

    • Anne E. Geller
    • Rejeena Shrestha
    • Jun Yan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • This analysis provides 108 noncoding CRISPR screens collated by the ENCODE4 consortium and establishes experimental guidelines for future CRISPRi screens characterizing functional cis-regulatory elements.

    • David Yao
    • Josh Tycko
    • Steven K. Reilly
    ResearchOpen Access
    Nature Methods
    Volume: 21, P: 723-734

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57