Xkr4 apoptotic scramblase activation is thought to involve caspase cleavage and dimerization to expose phosphatidylserine on dying cells. The authors show that full-length Xkr4 is an active monomeric scramblase. CryoEM reveals a conformation that promotes membrane thinning and scrambling, enhancing understanding of hXkr4 activity.
- Sayan Chakraborty
- Zhang Feng
- Alessio Accardi
