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Showing 1–2 of 2 results
Advanced filters: Author: Kalum Clayton Clear advanced filters

  • Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in the skin. Here the authors show, by transcriptomic, epigenetic and CRISPR editing analyses, that during LC migration and maturation the transcription factor IRF4 regulates expression of antigen presentation and co-stimulatory gene modules while attenuating inflammatory response genes.

    • Sofia Sirvent
    • Andres F. Vallejo
    • Marta E. Polak
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Inflammatory skin diseases are frequently associated with dysregulation of cutaneous immunity. Here the authors perform human challenge with house dust mite allergen in patients with atopic dermatitis and explore the molecular network determining tolerance versus inflammation and identify a role for metallothioneins in the modulation of allergen induced inflammation.

    • Sofia Sirvent
    • Andres F. Vallejo
    • Marta E. Polak
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14