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Showing 1–2 of 2 results
Advanced filters: Author: Kamil Sekulski Clear advanced filters

  • Regulation of 60S biogenesis remains poorly understood. Using cryo-EM, the authors show that failure of Spb1 to methylate the A-loop nucleotide G2922  prematurely activates the GTPase Nog2, suggesting that Spb1 and Nog2 form a kinetic checkpoint during ribosome maturation.

    • Kamil Sekulski
    • Victor Emmanuel Cruz
    • Jan P. Erzberger
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Cruz et al. present cryo-EM structures of large ribosomal subunit assembly intermediates that reveal how the DEAD-box helicase Spb4 remodels rRNA secondary structures to facilitate and guide 60S maturation.

    • Victor Emmanuel Cruz
    • Kamil Sekulski
    • Jan P. Erzberger
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1228-1238