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Showing 1–3 of 3 results

Advanced filters: Author: Kanako Kuwasako Clear advanced filters

RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing

Alternative pre-mRNA splicing is often jointly controlled by multiple splicing factors. Here Muto and colleagues elucidate the structural basis for cooperative RNA recognition by two splicing regulators required for tissue-specific expression of C. elegans FGFR.

Kanako Kuwasako
Mari Takahashi
Yutaka Muto
Research17 Aug 2014
Nature Structural & Molecular Biology

Volume: 21, P: 778-786
Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1

U2AF1 binds to the 3’ splice site of introns and its mutation lead to abnormal splicing. Here the authors solve the crystal structures of wild type and pathogenic mutant U2AF1 bound to target RNA, showing that different target sequence is preferred by pathogenic mutant.

Hisashi Yoshida
Sam-Yong Park
Eiji Obayashi
ResearchOpen Access21 Sept 2020
Nature Communications

Volume: 11, P: 1-9
Stalled ribosome rescue factors exert different roles depending on types of antibiotics in Escherichia coli

Mayu Mikami
Hidehiko Shimizu
Nobukazu Nameki
ResearchOpen Access02 Sept 2024
npj Antimicrobials and Resistance

Volume: 2, P: 1-14