Numata et al examine whether the TRPM7 ion channel plays a role in the activation of volume-sensitive outwardly rectifying Cl− channels (VSOR) using human and chicken cell lines. By genetically-manipulating the expression of TRPM7 and performing electrophysiology, they demonstrate that TRPM7 is an essential regulator of VSOR activity.
- Tomohiro Numata
- Kaori Sato-Numata
- Yasunobu Okada
