The authors investigated the effects and mechanism of IL-10 in renal ischemia-reperfusion injury (IRI). Compared to wild-type mice with IRI, IL-10 knockout (IL-10 KO) mice with IRI demonstrated decreased renal function, increased mRNA expressions of the pro-inflammatory cytokines, and increased expression of the pro-apoptosis factors. Our findings demonstrate that IL-10 suppresses the production of pro-inflammatory cytokines, renal dysfunction and the expression of pro-apoptosis factors after IRI.
- Kenji Sakai
- Yuji Nozaki
- Itaru Matsumura
