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Showing 1–13 of 13 results
Advanced filters: Author: Kara A. Bernstein Clear advanced filters

  • The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

    • Alex G. Contreras
    • Skylar Walters
    • Timothy J. Hohman
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • The tumor suppressor RAD51C is mutated in ovarian cancers. Through variant analysis the authors identify a mutation cluster in the RAD51C Walker B region important for the repair of DNA double-strand breaks and replicative damage. By identifying Walker B separation-of-function alleles, they show that these activities can be uncoupled.

    • Hayley L. Rein
    • Yashpal Rawal
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The presence of DNA lesions is a clear signal that initiates the DNA damage response; however, the mechanisms that attenuate this response when repair has occurred are less clear. Here, deacetylation of Sae2 by Rpd3 and Hda1 is shown to be required for it to act on Mre11. When the role of Sae2 in resection is completed, it is acetylated by Gcn5 and degraded through an autophagic pathway. This work highlights links between DNA damage signalling, acetylation of repair factors, and autophagy mediated degradation of these factors.

    • Thomas Robert
    • Fabio Vanoli
    • Marco Foiani
    Research
    Nature
    Volume: 471, P: 74-79

  • The human Shu complex promotes homologous recombination by regulating RAD51. Here the authors reveal that the Shu complex proteins, SWSAP1-SWS1, decorate the RAD51 filament on ssDNA and facilitate its strand exchange reaction by stimulating RPA diffusion on ssDNA. Lastly, that SWSAP1-SWS1 knockouts are Olaparib sensitive.

    • Sarah R. Hengel
    • Katherine G. Oppenheimer
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Homologous repair of DNA double strand breaks in Saccharomyces cerevisiaeis dependent on several conserved Rad51 paralogs. Here the authors provide biochemical evidence that Rad55-Rad57 synergistically interacts with the Shu complex to promote Rad51 filament formation and homology directed repair.

    • William A. Gaines
    • Stephen K. Godin
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. Here the authors reveal roles for the mouse SWS1–SWSAP1–SPIDR complex in inter-homolog recombination, including during meiosis, and sister chromatid exchange in BLM helicase deficient cells.

    • Rohit Prakash
    • Thomas Sandoval
    • Maria Jasin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • The homologous recombination machinery needs to be recruited at replication intermediates for accurate functioning. Here, the authors reveal that a Rad51 paralog-containing complex, called the Shu complex, recognizes and enables tolerance of predominantly lagging strand abasic sites.

    • Joel C. Rosenbaum
    • Braulio Bonilla
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57