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Proapoptotic Bid Association with Mre11-Rad50-Nbs1 Complex is Indispensable for Checkpoint Activation after DNA Damage

Van B. T. Ta
Karel Bezstarosti
Stephan P. Persengiev
ResearchOpen Access03 Oct 2007
Nature Precedings

P: 1
Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Wendrich, Gallant and colleagues find that USP53 and USP54 are active deubiquitinases, with USP53 removing ubiquitin chains from substrate proteins in a chain-linkage-directed manner, and provide biochemical and structural insights into their mechanism, cellular substrates and disease implications.

Kim Wendrich
Kai Gallant
Malte Gersch
ResearchOpen Access25 Nov 2024
Nature Chemical Biology

Volume: 21, P: 746-757
Publisher Correction: Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Marit E. Geijer
Di Zhou
Jurgen A. Marteijn
Amendments and Corrections23 Jun 2021
Nature Cell Biology

Volume: 23, P: 809
The small CRL4^CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics

Transcription-Coupled Nucleotide Excision Repair (TC-NER) removes transcription-blocking DNA lesions. This study reveals that DDA1 is a crucial player in TC-NER, protecting transcription programs against genotoxic insults.

Diana A. Llerena Schiffmacher
Shun-Hsiao Lee
Alex Pines
ResearchOpen Access29 Jul 2024
Nature Communications

Volume: 15, P: 1-17
Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability

Two side-by-side papers report that the transcription elongation factor ELOF1 drives transcription-coupled repair and prevents replication stress.

Marit E. Geijer
Di Zhou
Jurgen A. Marteijn
Research09 Jun 2021
Nature Cell Biology

Volume: 23, P: 608-619
Control of developmentally primed erythroid genes by combinatorial co-repressor actions

Conserved sets of transcription factors (TFs) regulate hematopoiesis. Here, Stadhouders et al. show that IRF2BP2 is a component of the LDB1 TF complex and together with its co-repressor ETO2, enhances transcriptional repression, which plays a crucial role at the erythroid progenitor stage.

Ralph Stadhouders
Alba Cico
Eric Soler
ResearchOpen Access23 Nov 2015
Nature Communications

Volume: 6, P: 1-17
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

Fisher and colleagues find that Jarid2 is a subunit of PRC2 (Polycomb Repressor Complex 2) that recruits PRC1 complex and Ser 5-phosphorylated RNA Polymerase II to developmental regulators in embryonic stem (ES) cells. Jarid2-deficient ES cells do not efficiently differentiate to mesoderm or neural lineages in vitro.

David Landeira
Stephan Sauer
Amanda G. Fisher
Research16 May 2010
Nature Cell Biology

Volume: 12, P: 618-624
HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design

Amy L. Kessler
Roel F. A. Pieterman
Sonja I. Buschow
ResearchOpen Access18 Jan 2025
npj Vaccines

Volume: 10, P: 1-13
Distinct proteomic profiles in prefrontal subareas of elderly major depressive disorder and bipolar disorder patients

Yang-Jian Qi
Yun-Rong Lu
Ai-Min Bao
ResearchOpen Access11 Jul 2022
Translational Psychiatry

Volume: 12, P: 1-11

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