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Showing 1–2 of 2 results
Advanced filters: Author: Karen Frudd Clear advanced filters

  • A flexible and compact database containing rare variant genotypes and phenotypes of 77,539 participants sequenced by the 100,000 Genomes Project enables the identification of new disease-causing genes.

    • Daniel Greene
    • Daniela Pirri
    • Ernest Turro
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 679-688

  • A dysfunction of autophagy can be detected in aged tissues, but how this is regulated is unclear. Here, the authors show in vitro and in aged mice aorta, that inhibition of LC3 lipidation under conditions of oxidative stress causes oxidation of Atg3 and Atg7, preventing autophagosome maturation.

    • Karen Frudd
    • Thomas Burgoyne
    • Joseph Robert Burgoyne
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15