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Showing 1–8 of 8 results
Advanced filters: Author: Karim-Jean Armache Clear advanced filters

  • Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining epigenetic inheritance.

    • Victoria Godínez López
    • Marco Igor Valencia-Sánchez
    • Karim-Jean Armache
    Research
    Nature
    Volume: 636, P: 755-761

  • The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with the histone H4 tail irrespective of K16 acetylation; a modification that regulates accessibility to chromatin.

    • Pablo De Ioannes
    • Victor A. Leon
    • Karim-Jean Armache
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The cryo-EM structure of DNA-assembled histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus, a nucleocytoplasmic large DNA virus, reveals that these proteins form viral nucleosomes with highly conserved features when compared to canonical eukaryotic nucleosomes.

    • Marco Igor Valencia-Sánchez
    • Stephen Abini-Agbomson
    • Karim-Jean Armache
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 413-417

  • Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose silencing activity is regulated in part by the selective incorporation of its catalytic subunits EZH1 or EZH2. Here, the authors capture an EZH1-containing PRC2 dimer on a nucleosome, demonstrating significant conformational changes during the process.

    • Daniel Grau
    • Yixiao Zhang
    • Karim-Jean Armache
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Transcription of eukaryotic protein-coding genes is initiated by RNA polymerase II (Pol II) in a complex with transcription factors including the transcription factor IIB (B). The crystal structure of the complete Pol II–B complex is now presented with complementary functional data. The results shed light on the mechanism of transcription initiation, including the transition to RNA elongation.

    • Dirk Kostrewa
    • Mirijam E. Zeller
    • Patrick Cramer
    Research
    Nature
    Volume: 462, P: 323-330

  • The histone variant H3.3 is phosphorylated at Ser31 in induced genes, and this selective mark stimulates the histone methyltransferase SETD2 and ejects the ZMYND11 repressor, thus revealing a role for histone phosphorylation in amplifying de novo transcription.

    • Anja Armache
    • Shuang Yang
    • Steven Z. Josefowicz
    Research
    Nature
    Volume: 583, P: 852-857

  • RNA is implicated in the targeting and function of Polycomb Group (PcG) chromatin regulators. Here the authors show that R-loops, three-stranded nucleic acid structures formed by DNA and RNA, are formed at some PcG binding sites in flies, as they are in mammals. Fly PRC2 can drive formation of RNA-DNA hybrids in vitro.

    • Célia Alecki
    • Victoria Chiwara
    • Nicole J. Francis
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Here, the authors show that anchoring of the PRC2 complex to its own sites requires nuclear condensation of Ccc1, a H3K27me3 reader in the yeast Cryptococcus neoformans, suggesting a functional role for condensates in ensuring heterochromatin fidelity.

    • Sujin Lee
    • Stephen Abini-Agbomson
    • Hiten D. Madhani
    Research
    Nature Structural & Molecular Biology
    Volume: 30, P: 891-901