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Showing 1–10 of 10 results

Advanced filters: Author: Karin Berghoff Clear advanced filters

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficacy of TREM2 agonism informing current clinical efforts.

Astrid F. Feiten
Kilian Dahm
Christian Haass
ResearchOpen Access24 Jan 2026
Nature Communications

P: 1-22
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial

Findings from the TUXEDO-1 trial demonstrate efficacy of the antibody–drug conjugate trastuzumab deruxtecan for treatment of brain metastases in patients with HER2-positive breast cancer.

Rupert Bartsch
Anna Sophie Berghoff
Matthias Preusser
ResearchOpen Access08 Aug 2022
Nature Medicine

Volume: 28, P: 1840-1847
Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases

Angelika M. Starzer
Ariane Steindl
Anna S. Berghoff
ResearchOpen Access21 Jan 2021
British Journal of Cancer

Volume: 124, P: 1294-1300
Podoplanin expression is associated with local inflammation and survival in glioma

Pegah Mir Seyed Nazari
Maximilian J. Mair
Anna Sophie Berghoff
ResearchOpen Access29 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Correction: Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases

Angelika M. Starzer
Ariane Steindl
Anna S. Berghoff
Amendments and Corrections10 Feb 2022
British Journal of Cancer

Volume: 126, P: 968
Randomised Phase 1b/2 trial of tepotinib vs sorafenib in Asian patients with advanced hepatocellular carcinoma with MET overexpression

Baek-Yeol Ryoo
Ann-Li Cheng
Shukui Qin
ResearchOpen Access10 May 2021
British Journal of Cancer

Volume: 125, P: 200-208
Efficacy and safety of tepotinib in Asian patients with advanced NSCLC with MET exon 14 skipping enrolled in VISION

Terufumi Kato
James Chih-Hsin Yang
Paul K. Paik
ResearchOpen Access04 Apr 2024
British Journal of Cancer

Volume: 130, P: 1679-1686
Phase 1b/2 trial of tepotinib in sorafenib pretreated advanced hepatocellular carcinoma with MET overexpression

Thomas Decaens
Carlo Barone
Sandrine Faivre
ResearchOpen Access06 Apr 2021
British Journal of Cancer

Volume: 125, P: 190-199
A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

Mark T. J. van Bussel
Ahmad Awada
Jan H. M. Schellens
ResearchOpen Access24 Nov 2020
British Journal of Cancer

Volume: 124, P: 728-735
Correction: Phase 1b/2 trial of tepotinib in sorafenib pretreated advanced hepatocellular carcinoma with MET overexpression

Thomas Decaens
Carlo Barone
Sandrine Faivre
Amendments and CorrectionsOpen Access02 Jun 2021
British Journal of Cancer

Volume: 125, P: 465