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Showing 1–9 of 9 results
Advanced filters: Author: Karin D. Prummel Clear advanced filters

  • Clonal haematopoiesis of indeterminate potential is driven by somatic mutations in hematopoietic stem/progenitor cells and may progress to myelodysplastic syndromes (MDS). Here authors show that the two conditions share a similar pattern of bone marrow remodeling, characterized by the emergence of inflammatory mesenchymal stromal cells and IFN-responsive T cells, reinforcing their shared etio-pathology.

    • Karin D. Prummel
    • Kevin Woods
    • Borhane Guezguez
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-25

  • Numerous tissues are derived from the lateral plate mesoderm (LPM) but how this is specified is unclear. Here, the authors identify a pan-LPM reporter activity found in the zebrafish draculin (drl) gene that also shows transgenic activity in LPM-corresponding territories of several chordates, including chicken, axolotl, lamprey, Ciona, and amphioxus.

    • Karin D. Prummel
    • Christopher Hess
    • Christian Mosimann
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The evolutionary water-to-land transition involved the separation of the skull from the pectoral girdle, though these musculoskeletal changes have not been deeply characterised. Here they show that the neck evolved from muscle groups present in fishes which were co-opted to acquire novel functions adapted to terrestrial lifestyle.

    • Eglantine Heude
    • Hugo Dutel
    • Shahragim Tajbakhsh
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • We identify that the larval zebrafish unpaired pre-anal fin fold is derived from the lateral plate mesoderm, can be readily duplicated, and thus may represent a developmental intermediate between median and paired fins.

    • Keh-Weei Tzung
    • Robert L. Lalonde
    • Tom J. Carney
    ResearchOpen Access
    Nature
    Volume: 618, P: 543-549

  • Mechanisms coupling Hox genes to neural crest are largely unknown. Here, the authors use cross species regulatory comparisons between the Hox2 genes of jawed vertebrates and lamprey, a jawless vertebrate, finding a conserved ancestral mechanism for Hox2 neural crest regulation.

    • Hugo J. Parker
    • Bony De Kumar
    • Robb Krumlauf
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • The mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-activation to mesothelioma tumors.

    • Karin D. Prummel
    • Helena L. Crowell
    • Christian Mosimann
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Late-differentiating second heart field progenitors contribute to atrium, ventricle, and outflow tract in the zebrafish heart but how remains unclear. Here, the authors image heart formation in transgenics based on the cardiopharyngeal gene tbx1 and show that progenitors are continuously added.

    • Anastasia Felker
    • Karin D. Prummel
    • Christian Mosimann
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Single-cell analysis of gene expression in metastatic cells from distinct human breast tumour models shows that early metastatic cells possess basal, stem and mesenchymal cell properties, whereas advanced metastatic cells have more proliferative properties and are more mature, enabling them to be targeted with an anti-proliferative compound.

    • Devon A. Lawson
    • Nirav R. Bhakta
    • Zena Werb
    Research
    Nature
    Volume: 526, P: 131-135