Nature Search

Injectable bioresorbable conductive hydrogels for multimodal brain tumor electroimmunotherapy

Injectable conductive hydrogels offer a promising alternative for tumor electrotherapy. Here, the authors develop highly conductive injectable bioresorbable soft electrode that enable minimally invasive glioblastoma electroimmunotherapy, achieving tumor ablation and robust immune activation.

Amit Singh Yadav
Umut Aydemir
Roger Olsson
ResearchOpen Access03 Nov 2025
Nature Communications

Volume: 16, P: 1-12
Parallel within-host evolution alters virulence factors in an opportunistic Klebsiella pneumoniae during a hospital outbreak

Multidrug-resistant Klebsiella pneumoniae is a critical priority pathogen. Here, the authors explore its evolution in 110 patients during a hospital outbreak, highlighting selected mutation-driven adaptations that alter its key virulence traits.

Greta Zaborskytė
Karin Hjort
Linus Sandegren
ResearchOpen Access30 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Hydrogenosomes in the diplomonad Spironucleus salmonicida

Hydrogenosomes and mitosomes are mitochondria-related organelles with distinct properties. Here the authors find that the mitochondria-related organelle of the salmon parasite Spironucleus salmonicidahas characteristics of both diplomonad mitosomes and of parabasalid hydrogenosomes, suggesting the presence of hydrogenosomes in the last common ancestor.

Jon Jerlström-Hultqvist
Elin Einarsson
Staffan G. Svärd
ResearchOpen Access17 Sept 2013
Nature Communications

Volume: 4, P: 1-9
The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification

Heteroresistance in pathogenic bacterial clinical isolates is widespread and is mediated by unstable tandem amplification of resistance-associated genes.

Hervé Nicoloff
Karin Hjort
Dan I. Andersson
Research11 Feb 2019
Nature Microbiology

Volume: 4, P: 504-514
In situ assembly of an injectable cardiac stimulator

Heart pacing devices are bulky or rely on surgery. Here, the authors present an injectable cardiac stimulator based on a nanoparticle solution which attaches to the heart and forms a conductive path to the skin for external connection. It can regulate heartbeats and is thereafter cleared from the body.

Umut Aydemir
Abdelrazek H. Mousa
Roger Olsson
ResearchOpen Access08 Aug 2024
Nature Communications

Volume: 15, P: 1-12
Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance

Bacterial heteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Here, Nicoloff et al. describe how three different mechanisms that increase the copy number of resistance genes can lead to unstable and transient heteroresistance.

Hervé Nicoloff
Karin Hjort
Helen Wang
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-12
In situ assembly of bioresorbable organic bioelectronics in the brain

Temporary bioelectronics can complement classical therapies in non-chronic treatments. Here, the authors describe the minimally invasive implantation of bioresorbable electrodes in the brain that form in situ from water-dispersed nanoparticles and show no tissue damage after bioresorption.

Martin Hjort
Abdelrazek H. Mousa
Roger Olsson
ResearchOpen Access24 Jul 2023
Nature Communications

Volume: 14, P: 1-13
Evolution of high-level resistance during low-level antibiotic exposure

Mutational antibiotic resistance can emerge under either high or low antibiotic levels. Here, the authors show several small-effect resistance mutations are combined to confer high-level resistance in Salmonella enterica exposed to sub-MIC levels of streptomycin.

Erik Wistrand-Yuen
Michael Knopp
Dan I. Andersson
ResearchOpen Access23 Apr 2018
Nature Communications

Volume: 9, P: 1-12
Mechanisms and clinical relevance of bacterial heteroresistance

In this Review, Andersson and colleagues outline factors to consider when studying and defining heteroresistance, and they explore the different genetic mechanisms underlying heterogeneity in antibiotic resistance phenotypes, the impact of such mechanisms on the efficacy of treatment and the methods and difficulties in diagnosing heteroresistance in clinical bacterial isolates.

Dan I. Andersson
Hervé Nicoloff
Karin Hjort
Reviews24 Jun 2019
Nature Reviews Microbiology

Volume: 17, P: 479-496
Author Correction: Inhibition of translation termination by small molecules targeting ribosomal release factors

Xueliang Ge
Ana Oliveira
Johan Åqvist
Amendments and CorrectionsOpen Access13 Mar 2020
Scientific Reports

Volume: 10, P: 1
The highly dynamic nature of bacterial heteroresistance impairs its clinical detection

Bacterial populations can show heteroresistance, where an antibiotic resistant subpopulation is part of a susceptible one. Pereira et al. show in Escherichia coli and Salmonella enterica that disk diffusion, a common antibiotic susceptibility test, underestimates the occurrence of heteroresistance in clinical isolates.

Cátia Pereira
Jimmy Larsson
Dan I. Andersson
ResearchOpen Access05 May 2021
Communications Biology

Volume: 4, P: 1-12
A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

Komal Umashankar Rao
Domhnall Iain Henderson
Gabriela Godaly
ResearchOpen Access18 Feb 2021
Scientific Reports

Volume: 11, P: 1-9
Inhibition of translation termination by small molecules targeting ribosomal release factors

Xueliang Ge
Ana Oliveira
Johan Åqvist
ResearchOpen Access28 Oct 2019
Scientific Reports

Volume: 9, P: 1-10
N¹-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism

Kristoffer Ström
David Morales-Alamo
Ola Hansson
ResearchOpen Access14 Feb 2018
Scientific Reports

Volume: 8, P: 1-12

Search

Injectable bioresorbable conductive hydrogels for multimodal brain tumor electroimmunotherapy

Parallel within-host evolution alters virulence factors in an opportunistic Klebsiella pneumoniae during a hospital outbreak

Hydrogenosomes in the diplomonad Spironucleus salmonicida

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification

In situ assembly of an injectable cardiac stimulator

Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance

In situ assembly of bioresorbable organic bioelectronics in the brain

Evolution of high-level resistance during low-level antibiotic exposure

Mechanisms and clinical relevance of bacterial heteroresistance

Author Correction: Inhibition of translation termination by small molecules targeting ribosomal release factors

The highly dynamic nature of bacterial heteroresistance impairs its clinical detection

A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

Inhibition of translation termination by small molecules targeting ribosomal release factors

N¹-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism

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